Tet2 is one of the most frequently mutated genes in hematological malignancies. Importantly, studies using various mouse models have demonstrated that TET proteins can act as tumor suppressors. We will take advantage of mouse models of hematological cancers with TET mutations to dissect the impact of TET protein loss in cancer emergence.

Pathway enrichment analysis of differentially expressed genes in Tet2/3 DKO iNKT cells that have cancerous traits. With purple are highlighted the genes related to biological processes such as: DNA replication, cell cycle and DNA repair. With green are shown categories related to T cell function. (Tsagaratou et al, Nat Immunol. 2017 Jan;18(1):45-53.)